End Fatigue

Acetyl-L-Carnitine Effective in Treatment of Opiate Withdrawal

Although most pain can be effectively treated without narcotics (opiates), most physicians are simply not trained in pain management and will (often from compassion) use these as they are not aware of alternatives (see my book Pain Free 1-2-3 for how to eliminate pain without narcotics). Weaning off narcotics can be hard, but natural supplements, like Acetyl-L-Carnitine, decrease withdrawal symptoms significantly.

In this two-part placebo controlled study, Acetyl-L-Carnitine (ALC) was found to be effective at reducing symptoms of opiate withdrawal in both humans and mice. In the human study, 30 subjects with methadone dependence were treated with 2,000 mg a day ALC for a 3 week detoxification period, or a placebo. Subjects who received ALC were found to have significantly lower total scores on the Average Short Opiate Withdrawal Syndrome scale the first 5 days of treatment, and significantly lower pain scores after 1 week of treatment through study end, including reduction of symptoms such as muscular tension, cramps, and insomnia, compared to those receiving placebo. The authors conclude, "Considering its tolerability, the excellent side effect profile, the absence of significant interactions, and the lack of abuse potential, ALC can be considered as a useful pharmacological adjunct in the treatment of opiate withdrawal."

References

"Acetyl-l-Carnitine in the Management of Pain During Methadone Withdrawal Syndrome," Janiri L, Martinotti G, et al, Clin Neuropharmacol, 2008 Oct 23; [Epub ahead of print].