Skip to Navigation | Skip To Content

Nitroglycerine Spray For Diabetic Neuropathy

Glyceryl-Trinitrate Spray Effective for Painful Diabetic Neuropathy


Reuters Health Information 2007. © 2007 Reuters Ltd.

Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

By C. Vidyashankar, MD

CHENNAI, India (Reuters Health) Jun 29 - While it's normally used as a vasodilator in angina pectoris, glyceryl-trinitrate produces a significant improvement in pain associated with diabetic neuropathy, researchers from India report.

In a double-blind, placebo-controlled crossover trial, Dr. R.P. Agrawal and colleagues from the S. P. Medical College, Bikaner in western India, evaluated the efficacy of topical glyceryl-trinitrate spray in 48 patients with painful diabetic neuropathy.

Twenty-four patients in the study group used glyceryl-trinitrate spray topically on their legs at bedtime for four weeks, while the other 24 used a placebo spray. After a wash-out period of 2 weeks, the participants switched to the opposite arm for a further for 4 weeks. The severity of pain was assessed using the McGill pain questionnaire, visual analogue score, present pain intensity score and 11-point Lickert scale.

On completion of the trial, all the pain scores were significantly lower while the patients were receiving glyceryl-trinitrate spray rather than the placebo, Dr. Agrawal and colleagues report in the August 2006 issue of Diabetes Research and Clinical Practice.

The analgesic effects persisted till the next application and improved sleep satisfaction, the researchers add.

Glyceryl-trinitrate was well tolerated and only one patient was withdrawn from the study because of adverse effects.

Vasodilation due to nitric oxide, a derivative of glyceryl-trinitrate, may explain its analgesic effects, while stimulation of angiogenesis in the blood vessels supplying the nerves could explain the temporal increase in the analgesic effects with continued usage, Dr. Agrawal's team suggests.



This Week's Special Offers

The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition. The information on this website is not intended to diagnose, treat, cure or prevent any disease.

Sign In